The Mushroom Kingdom has been hit by a virus, and it's up to Dr. Mario to wipe it out.
You are presented with a jar containing three colored viruses. Mario throws two-colored pills into the jar and you have to move and rotate them so they form lines of four of the same color to make the line vanish. If the pills hit the neck of the jar then you have to start again. Clear the jar of viruses to advance to the next stage.
As well as a stage-by-stage game with an increasing number of viruses, you can also play a 2-Player game against another player, where scoring combos will drop additional pill segments into your opponent's jar.
Released alongside the NES version, the Game Boy release features the same gameplay and game modes. Due to the hardware's limitations, the viruses appear as black, white and gray, and the 2P Mode can only be played using a Game Boy Link Cable and two copies of the game.
Dr. Mario (Super Famicom Version)
The Super Famicom version was released exclusively through the Nintendo Power download service. It features updated graphics and sound, but the gameplay and game modes are identical to those of the NES version.
Famicom / NES Version
Game Boy Version
VS. Dr. Mario
Super Famicom (Nintendo Power) Version